Reactome | DIS3L2 [cytosol]

DIS3L2 [cytosol]

Stable Identifier

R-HSA-9820867

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fullName evidence="1"DIS3-like exonuclease 2, DI3L2_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8IYB7 DIS3L2

Gene Names

DIS3L2, FAM6A

Chain

chain:1-885

Reference Genes

BioGPS Gene:129563 DIS3L2

COSMIC (genes):DIS3L2 DIS3L2

CTD Gene:129563 DIS3L2

dbSNP Gene:129563 DIS3L2

ENSEMBL:ENSG00000144535 DIS3L2

ENSEMBL_homo_sapiens_GENE:ENSG00000144535.20 DIS3L2

HGNC:28648 DIS3L2

KEGG Gene (Homo sapiens):129563 DIS3L2

Monarch:129563 DIS3L2

NCBI Gene:129563 DIS3L2

OMIM:614184 DIS3L2

UCSC:Q8IYB7 DIS3L2

Reference Transcript

Other Identifiers

11743637_a_at

11743638_x_at

11744754_a_at

11752315_a_at

129563

16892178

227597_PM_at

227597_at

238602_PM_at

238602_at

242539_PM_at

242539_at

244304_PM_at

244304_at

2532111

2532112

2532114

2532116

2532122

2532123

2532136

2532143

2532154

2532155

2532156

2532157

2532158

2532159

2532160

2532162

2532164

2532174

2532179

2532190

2532195

2532198

2532199

2532200

2532212

2532216

2532217

2532218

2532220

2532221

2532223

2532224

2532226

2532227

2532229

2532230

2532231

2532232

2532233

2532234

2532235

2532236

2532237

2532238

2532239

2532244

2532245

2532246

2532247

2532248

2532249

2532317

2532324

2532327

65186_r_at

76728_at

8049097

81833_at

A_23_P113888

A_32_P232192

A_32_P64418

A_33_P3270192

A_33_P3270197

A_33_P3270203

A_33_P3422747

GO:0000175

GO:0000278

GO:0000287

GO:0000291

GO:0000932

GO:0003723

GO:0003824

GO:0004518

GO:0004527

GO:0004540

GO:0005515

GO:0005737

GO:0005844

GO:0006402

GO:0007049

GO:0007059

GO:0008266

GO:0008285

GO:0010587

GO:0016071

GO:0016787

GO:0019827

GO:0034427

GO:0043226

GO:0046872

GO:0051301

GO:0051306

GO:0140014

GO:0140098

GO:1990074

HMNXSV003001769

HMNXSV003010478

HMNXSV003013494

HMNXSV003041009

Hs.12755.0.A1_3p_s_at

Hs.132886.0.A1_3p_s_at

Hs.160159.0.A1_3p_s_at

Hs.270938.0.A1_3p_s_at

ILMN_1745737

PH_hs_0028066

TC02001396.hg

Participates

as an input of

DIS3L2 binds PABPN1 in PABPN1:uridylated mRNA complex (Homo sapiens)

as an output of

DIS3L2 hydrolyzes uridylated mRNA (Homo sapiens)

as a component of

DIS3L2:PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001244210.1, NP_001244211.1, NP_689596.4

OpenTargets

ENSG00000144535

GeneCards

Q8IYB7

HPA

ENSG00000144535-DIS3L2

Ensembl

ENSP00000273009, ENSG00000144535, ENST00000325385, ENSP00000386594, ENST00000273009, ENST00000390005, ENST00000433430, ENSP00000391175, ENST00000445090, ENSP00000374655, ENSP00000315569, ENST00000409401, ENSP00000388999

PRO

Q8IYB7

Pharos - Targets

Q8IYB7

PDB

8E28, 8E2A, 8E27, 8E29