AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote

Stable Identifier
R-HSA-9820842
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote
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Before and during zygotic genome activation, AGO2 bound to an endogenous small interfering RNA (endosiRNA) derived from transcripts of a maternally expressed gene (AGO2:endosiRNA) hydrolyzes the cognate maternal mRNA at the site of complementarity with the endosiRNA (inferred from mouse homologs). In mouse early embryos, Ago2 is involved in the decay of over half of the maternal mRNAs (Zhang et al. 2020).
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Catalyst Activity

endoribonuclease activity, cleaving siRNA-paired mRNA of AGO2:maternal endosiRNA [cytosol]

Physical Entity
AGO2:maternal endosiRNA [cytosol] (Homo sapiens)
Activity
endoribonuclease activity, cleaving siRNA-paired mRNA (GO:0070551)
Inferred From
Ago2:Zfp277 endosiRNA hydrolyzes Zfp277 mRNA (Mus musculus)
Authored
May, B  (2022-11-20)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-11-21)
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