M-decay: degradation of maternal mRNAs by maternally stored factors

Stable Identifier
R-HSA-9820841
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
M-decay: degradation of maternal mRNAs by maternally stored factors
Click the image above or here to open this pathway in the Pathway Browser
Maternal transcripts are transcribed from the maternal genome and accumulate in the oocyte during oogenesis. A subset of these maternal transcripts is degraded during later development of the unfertilized oocyte and after fertilization of the oocyte. Maternal decay of maternal transcripts (M-decay, reviewed in Jian and Fan 2022) refers to the degradation of maternal transcripts by maternally provided factors such as ZFP36L2 (inferred from the mouse homolog in Chousal et al. 2018, Sha et al. 2018), BTG4 (inferred from the mouse homolog in Liu et al. 2016, Yu et al. 2016, Pasternak et al. 2016, Zhao et al. 2020), and AGO2 (inferred from the mouse homolog in Zhang et al. 2020). ZFP36L2 acting before fertilization and BTG4 acting after fertilization recruit the CCR4-NOT deadenylation complex to the mRNA to initiate degradation. AGO2 is primed with endogenous small interfering RNAs (endosiRNAs) produced from double-stranded RNAs that originate from specific loci. The resulting AGO2:endosiRNA complexes bind and hydrolyze complementary maternal mRNAs. Similar patterns of mRNA decay are observed in human and mouse zygotes (Sha et al. 2020).
Literature References
PubMed ID Title Journal Year
29408237 Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2

Chousal, J, Cho, K, Ramaiah, M, Skarbrevik, D, Mora-Castilla, S, Stumpo, DJ, Lykke-Andersen, J, Laurent, LC, Blackshear, PJ, Wilkinson, MF, Cook-Andersen, H

Dev Cell 2018
30478191 CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte

Sha, QQ, Yu, JL, Guo, JX, Dai, XX, Jiang, JC, Zhang, YL, Yu, C, Ji, SY, Jiang, Y, Zhang, SY, Shen, L, Ou, XH, Fan, HY

EMBO J 2018
27190313 BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis

Liu, Y, Lu, X, Shi, J, Yu, X, Zhang, X, Zhu, K, Yi, Z, Duan, E, Li, L

J Mol Cell Biol 2016
27605379 The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs

Pasternak, M, Pfender, S, Santhanam, B, Schuh, M

Open Biol 2016
32558204 PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition

Zhao, LW, Zhu, YZ, Chen, H, Wu, YW, Pi, SB, Chen, L, Shen, L, Fan, HY

EMBO Rep 2020
27065194 BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes

Yu, C, Ji, SY, Sha, QQ, Dang, Y, Zhou, JJ, Zhang, YL, Liu, Y, Wang, ZW, Hu, B, Sun, QY, Sun, SC, Tang, F, Fan, HY

Nat Struct Mol Biol 2016
33298889 Argonaute 2 is a key regulator of maternal mRNA degradation in mouse early embryos

Zhang, JM, Hou, WB, Du, JW, Zong, M, Zheng, KL, Wang, WJ, Wang, JQ, Zhang, H, Mu, YS, Yin, Z, Ding, CM, Sun, QY, Liu, ZH, Kong, QR

Cell Death Discov 2020
33004802 Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

Sha, QQ, Zheng, W, Wu, YW, Li, S, Guo, L, Zhang, S, Lin, G, Ou, XH, Fan, HY

Nat Commun 2020
35098307 Five questions toward mRNA degradation in oocytes and preimplantation embryos: when, who, to whom, how, and why?†

Jiang, ZY, Fan, HY

Biol Reprod 2022
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
maternal-to-zygotic transition of gene expression (0160021)
Authored
May, B  (2022-11-20)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-11-21)
Cite Us!