DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA

Stable Identifier
R-HSA-9820840
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA
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In the zygote before and during zygotic genome activation, endogenous small interfering RNAs (endosiRNAs) are produced from double-stranded RNAs formed by gene-specific mRNAs and antisense long coding RNAs transcribed from the same locus (inferred from mouse zygotes). These endosiRNAs are presumed to be produced by the ribonuclease III-like endoribonuclease activity of DICER1.
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Catalyst Activity

ribonuclease III activity of DICER1 [cytosol]

Physical Entity
DICER1 [cytosol] (Homo sapiens)
Activity
ribonuclease III activity (GO:0004525)
Inferred From
Dicer1 hydrolyzes Zfp277 double-stranded RNA to yield Zfp277 endosiRNAs (Mus musculus)
Authored
May, B  (2022-11-20)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-11-21)
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