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GCGR [plasma membrane]
Stable Identifier
R-HSA-9820623
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Glucagon receptor, GLR_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Glucagon signaling in metabolic regulation (Homo sapiens)
Glucagon binds to Glucagon receptor (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Glucagon-type ligand receptors (Homo sapiens)
Glucagon binds to Glucagon receptor (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
GCGR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P47871 GCGR
Gene Names
GCGR
Chain
signal peptide:1-25, chain:26-477
Reference Genes
BioGPS Gene:2642 GCGR
COSMIC (genes):GCGR GCGR
CTD Gene:2642 GCGR
dbSNP Gene:2642 GCGR
ENSEMBL:ENSG00000215644 GCGR
ENSEMBL_homo_sapiens_GENE:ENSG00000215644.10 GCGR
ENSEMBL_homo_sapiens_GENE:ENSG00000288269.1 GCGR
HGNC:4192 GCGR
KEGG Gene (Homo sapiens):2642 GCGR
Monarch:2642 GCGR
NCBI Gene:2642 GCGR
OMIM:138033 GCGR
UCSC:P47871 GCGR
Reference Transcript
RefSeq:NM_000160.4 GCGR
RefSeq:XM_006722277.1 GCGR
Other Identifiers
11756776_a_at
16838901
210565_PM_at
210565_at
2642
32886_at
4040455
4040458
4040459
4040460
4040462
4040463
4040465
4040466
4040467
4040468
4040470
4040471
4040472
4040474
4040477
4040478
4040479
4040480
4040481
4040482
8019669
A_23_P15751
A_33_P3409467
GE62703
GO:0003013
GO:0004888
GO:0004930
GO:0004967
GO:0005085
GO:0005768
GO:0005886
GO:0005975
GO:0006091
GO:0006887
GO:0007165
GO:0007166
GO:0007186
GO:0007188
GO:0007189
GO:0007584
GO:0008217
GO:0009267
GO:0009755
GO:0010628
GO:0016020
GO:0016192
GO:0017046
GO:0023052
GO:0031410
GO:0038023
GO:0042593
GO:0042594
GO:0043226
GO:0060089
GO:0070873
GO:0071377
GO:0098772
HMNXSV003002082
ILMN_1725311
L20316_at
PH_hs_0027517
TC17000937.hg
g439689_3p_at
Participates
as an input of
Glucagon binds to Glucagon receptor (Homo sapiens)
as a component of
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
Inferred To
Gcgr [plasma membrane]
(Mus musculus)
Gcgr [plasma membrane]
(Rattus norvegicus)
GCGR [plasma membrane]
(Bos taurus)
GCGR [plasma membrane]
(Canis familiaris)
GCGR [plasma membrane]
(Gallus gallus)
GCGR [plasma membrane]
(Sus scrofa)
gcgr [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_006722340.1
,
NP_000151.1
Guide to Pharmacology - Targets
251
OpenTargets
ENSG00000215644
ZINC - Substances
GLR_HUMAN
ZINC target
P47871
PRO
P47871
PDB
6WHC
,
8JRV
,
8WG8
,
3CZF
,
8FU6
,
5EE7
,
6WPW
,
6LMK
,
4LF3
,
8JIQ
,
4ERS
,
4L6R
,
5XEZ
,
8JIU
,
8JRU
,
2A83
,
6LML
,
7V35
,
8JIT
ZINC - Investigational
GLR_HUMAN
GeneCards
P47871
HPA
ENSG00000215644-GCGR
Ensembl
ENSP00000500297
,
ENSG00000215644
,
ENST00000400723
,
ENSP00000383558
,
ENST00000671794
,
ENSG00000288269
Pharos - Targets
P47871
ZINC - Predictions - Purchasable
GLR_HUMAN
Orphanet
23527
HMDB Protein
HMDBP07710
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