Reactome | ZnT5 transports zinc into the golgi apparatus

ZnT5 transports zinc into the golgi apparatus

Stable Identifier

R-HSA-9820566

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)
        
        ZnT5 transports zinc into the golgi apparatus (Homo sapiens)

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ZnT5 transports zinc into the golgi apparatus

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Dimeric ZnT5/SLC30A5 mediates the transport of cytosolic Zn2+ into the lumen of the Golgi apparatus. The protein is expressed in human pancreatic beta cells and localizes with the Golgi apparatus and insulin-containing secretory granules (Bosco et al. 2010; Kambe et al. 2002; Kambe et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
21713314	Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation Zalewski, PD, Coates, PT, Lang, CJ, Mohanasundaram, DM, Drogemuller, CJ, Bosco, MD	Rev Diabet Stud	2010
33485965	Zinc transporters and their functional integration in mammalian cells Kambe, T, Fu, D, Taylor, KM	J Biol Chem	2021
11904301	Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells Nagao, M, Mori, K, Sasaki, R, Yamaguchi-Iwai, Y, Kambe, T, Amano, T, Hirose, J, Sugiura, N, Iwanaga, T, Narita, H	J Biol Chem	2002