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ZFP36L2 binds CNOT6L of CCR4-CNOT complex and an AU-rich element in mRNA
Stable Identifier
R-HSA-9819200
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
M-decay: degradation of maternal mRNAs by maternally stored factors (Homo sapiens)
ZFP36L2 binds CNOT6L of CCR4-CNOT complex and an AU-rich element in mRNA (Homo sapiens)
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In maturing oocytes ZFP36L2 binds AU-rich elements in specific maternal mRNAs and also CNOT6L, a catalytic component of the CCR4-NOT RNA deadenylase complex (inferred from mouse homologs). Knockout of CNOT6L prevents degradation of maternal transcripts related to translation in maturing oocytes (inferred from mouse oocytes). Depletion or knockout of ZFP36L2 causes defects in oocyte maturation (inferred from mouse oocytes) and prevents degradation of maternal mRNAs related to histone demethylation and regulation of transcription (inferred from mouse homologs), therefore ZFP36L2 is believed to regulate degradation of specific mRNAs in oocytes.
Participants
Input
CCR4-NOT Complex (CNOT6L) [cytosol]
(Homo sapiens)
mRNA regulated by ZFP36L2 [cytosol]
(Homo sapiens)
ZFP36L2 [cytosol]
(Homo sapiens)
Output
CCR4-NOT(CNOT6L):ZFP36L2:mRNA [cytosol]
(Homo sapiens)
Participates
as an event of
M-decay: degradation of maternal mRNAs by maternally stored factors (Homo sapiens)
Inferred From
Zfp36l2 binds Cnot6l of CCR4-CNOT complex and an AU-rich element in mRNA (Mus musculus)
Authored
May, B (2022-10-30)
Reviewed
Xie, W (2023-08-08)
Created
May, B (2022-11-02)
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