PSIP1 binds MLL1 and MEN1

Stable Identifier
R-HSA-9818954
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PSIP1 (also known as LEDGF) conjointly binds to KMT2A (also known as MLL1 or MLL) and MEN1 (menin) (Yokoyama and Cleary 2008; Huang et al. 2012). The LEDGF-binding motif (LBM) in the N-terminus of KMT2A is missing in KMT2B (Huang et al. 2012), but the interaction of PSIP1 with MEN1-bound MLL2 complexes has been reported (van Nuland et al. 2013). Based on quantitative studies in HeLa cells, all PSIP1-containing MLL1/MLL2 complexes contain MEN1, but only about 25% of MEN1-containing MLL1/MLL2 complexes contain PSIP1 (van Nuland et al. 2013). HCFC2 has been found to be co-immunoprecipitated with PSIP1, so it is possible that a portion of MLL1 complexes with MEN1 and PSIP1 also include HCFC1 or HCFC2 (van Nuland et al. 2013).
Literature References
PubMed ID Title Journal Year
23508102 Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes

Pallaki, P, Smits, AH, van Nuland, R, Jansen, PW, Timmers, HT, Vermeulen, M

Mol Cell Biol 2013
22327296 The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

Lei, M, Huang, J, Wan, K, Veniaminova, NA, Hua, X, Matkar, S, Gurung, B, Wan, B, Merchant, JL

Nature 2012
18598942 Menin critically links MLL proteins with LEDGF on cancer-associated target genes

Cleary, ML, Yokoyama, A

Cancer Cell 2008
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