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KMT2A dimer [nucleoplasm]
Stable Identifier
R-HSA-9818587
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
KMT2A(1-2718):KMT2A(2719-3969)
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
Core MLL complex, SMYD3, PRDM9 [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
AKAP8L binds MLL1 complex (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MLL1 complex:AKAP8L [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
Cleaved KMT2A dimers translocate to the nucleus (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
Formation of the MLL1 complex (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
HCFC1, HCFC2 bind the MLL1:MEN1 complex (Homo sapiens)
MLL1 complex,MLL1 complex:MEN1 [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MLL1 complex:MEN1 [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MLL1 complex,MLL1 complex:MEN1:HCFC1,HCFC2 [nucleoplasm] (Homo sapiens)
MLL1 complex:HCFC1 [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MLL1 complex:HCFC2 [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MLL1 complex:MEN1:HCFC1 [nucleoplasm] (Homo sapiens)
MLL1 complex:MEN1 [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MLL1 complex:MEN1:HCFC2 [nucleoplasm] (Homo sapiens)
MLL1 complex:MEN1 [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MEN1 binds MLL1 complex (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MLL1 complex:MEN1 [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
PSIP1 binds MLL1 and MEN1 (Homo sapiens)
MLL1 complex:MEN1 [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MLL1 complex:MEN1:PSIP1 [nucleoplasm] (Homo sapiens)
MLL1 complex:MEN1 [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
MLL1 complex [nucleoplasm] (Homo sapiens)
KMT2A dimer [nucleoplasm] (Homo sapiens)
Participants
components
KMT2A(1-2718) [nucleoplasm]
(Homo sapiens)
KMT2A(2719-3969) [nucleoplasm]
(Homo sapiens)
Participates
as an output of
Cleaved KMT2A dimers translocate to the nucleus (Homo sapiens)
as an input of
Formation of the MLL1 complex (Homo sapiens)
as a component of
MLL1 complex [nucleoplasm] (Homo sapiens)
Inferred To
KMT2A dimer [nucleoplasm]
(Bos taurus)
KMT2A dimer [nucleoplasm]
(Canis familiaris)
KMT2A dimer [nucleoplasm]
(Drosophila melanogaster)
KMT2A dimer [nucleoplasm]
(Gallus gallus)
KMT2A dimer [nucleoplasm]
(Mus musculus)
KMT2A dimer [nucleoplasm]
(Rattus norvegicus)
KMT2A dimer [nucleoplasm]
(Sus scrofa)
KMT2A dimer [nucleoplasm]
(Xenopus tropicalis)
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