Reactome | ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen

ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen

Stable Identifier

R-HSA-981809

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen

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The human genes ST6GALNAC3 and 4 encode GalNAc alpha-2,6-sialyltransferase III and IV respectively which can add sialic acid (Neu5Ac) to sialyl T antigen to produce a disialyl T antigen. ST6GALNAC4 is characterised (Harduin-Lepers et al. 2000) while ST6GALNAC3 is thought to perform a similar function based on sequence similarity.

Literature References

PubMed ID	Title	Journal	Year
11062056	Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV Harduin-Lepers, A, Stokes, DC, Steelant, WF, Samyn-Petit, B, Krzewinski-Recchi, MA, Vallejo-Ruiz, V, Zanetta, JP, Augé, C, Delannoy, P	Biochem J	2000