ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen

Stable Identifier
R-HSA-981809
Type
Reaction [transition]
Species
Homo sapiens
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The human genes ST6GALNAC3 and 4 encode GalNAc alpha-2,6-sialyltransferase III and IV respectively which can add sialic acid (Neu5Ac) to sialyl T antigen to produce a disialyl T antigen. ST6GALNAC4 is characterised (Harduin-Lepers et al. 2000) while ST6GALNAC3 is thought to perform a similar function based on sequence similarity.

Literature References
PubMed ID Title Journal Year
11062056 Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV

Harduin-Lepers, A, Stokes, DC, Steelant, WF, Samyn-Petit, B, Krzewinski-Recchi, MA, Vallejo-Ruiz, V, Zanetta, JP, Augé, C, Delannoy, P

Biochem J 2000
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Catalyst Activity
Title
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity of ST6GALNAC3/4 [Golgi membrane]
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Activity
Orthologous Events
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