ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen

Stable Identifier
R-HSA-981809
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
ReviewStatus
5/5
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ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen
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The human genes ST6GALNAC3 and 4 encode GalNAc alpha-2,6-sialyltransferase III and IV respectively which can add sialic acid (Neu5Ac) to sialyl T antigen to produce a disialyl T antigen. ST6GALNAC4 is characterised (Harduin-Lepers et al. 2000) while ST6GALNAC3 is thought to perform a similar function based on sequence similarity.
Literature References
PubMed ID Title Journal Year
11062056 Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV

Vallejo-Ruiz, V, Augé, C, Zanetta, JP, Harduin-Lepers, A, Delannoy, P, Samyn-Petit, B, Krzewinski-Recchi, MA, Steelant, WF, Stokes, DC

Biochem J 2000
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as an event of
Catalyst Activity

alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity of ST6GALNAC3/4 [Golgi membrane]

Physical Entity
ST6GALNAC3/4 [Golgi membrane] (Homo sapiens)
Activity
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity (GO:0047290)
Orthologous Events
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Bos taurus)
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Canis familiaris)
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Danio rerio)
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Gallus gallus)
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Mus musculus)
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Rattus norvegicus)
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Sus scrofa)
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Xenopus tropicalis)
Authored
Jassal, B  (2010-10-15)
Reviewed
Ferrer, A  (2011-11-04)
Created
Jassal, B  (2010-10-27)
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