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NFE2L2 regulating tumorigenic genes
Stable Identifier
R-HSA-9818030
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
Locations in the PathwayBrowser
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating tumorigenic genes (Homo sapiens)
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Sub-pathway representing tumor-inducing genes regulated by NFE2L2 (NRF2). NFE2L2 plays a key role in cancer progression by inducing cytoprotection, regulating cancer metabolism and also directly regulating the expression of pro-tumorogenic genes(Deblasi et al, 2020; Wu et al, 2019)
Participants
Events
AcK-NFE2L2 binds the AREG gene
(Homo sapiens)
NFE2L2 dependent AREG expression
(Homo sapiens)
AcK-NFE2L2 binds the BCL2 gene
(Homo sapiens)
NFE2L2 dependent BCL2 expression
(Homo sapiens)
AcK-NFE2L2 binds the BCL2L1 gene
(Homo sapiens)
NFE2L2 dependent BCL2L1 expression
(Homo sapiens)
AcK-NFE2L2 binds the EGF gene
(Homo sapiens)
NFE2L2 dependent EGF expression
(Homo sapiens)
AcK-NFE2L2 binds the NOTCH1 gene
(Homo sapiens)
NFE2L2 dependent NOTCH1 expression
(Homo sapiens)
AcK-NFE2L2 binds the PDGFA gene
(Homo sapiens)
NFE2L2 dependent PDGFA expression
(Homo sapiens)
Participates
as an event of
Nuclear events mediated by NFE2L2 (Homo sapiens)
Authored
Tiwari, K (2023-08-08)
Created
Tiwari, K (2022-10-10)
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