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NFE2L2 regulating inflammation associated genes
Stable Identifier
R-HSA-9818026
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating inflammation associated genes (Homo sapiens)
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Subpathway representing inflammatory genes regulated by NFE2L2. NFE2L2 plays a pivotal role in regulating inflammation directly (by regulating inflammation-related genes like CCL2, IL8) and indirectly (through the HO-1-NFKB axis). This role of NFE2L2 plays a role in inflammatory diseases and expands NFE2L2 role beyond the antioxidant system. (Ahmed et al, 2017; Saha et al, 2020)
Participants
Events
AcK-NFE2L2 binds the CCL2 gene
(Homo sapiens)
NFE2L2 dependent CCL2 expression
(Homo sapiens)
NFE2L2 negatively regulates IL8 mRNA degradation
(Homo sapiens)
Participates
as an event of
Nuclear events mediated by NFE2L2 (Homo sapiens)
Authored
Tiwari, K (2023-08-08)
Created
Tiwari, K (2022-10-10)
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