Expression of DUXB in the embryo

Stable Identifier
R-HSA-9817941
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of DUXB in the embryo
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The DUXB gene is transcribed to yield mRNA which is translated to yield protein. DUXB is both maternally expressed and activated in the embryo at the 4-cell stage and later (Tohonen et al. 2015). DUX4 (Hendrickson et al. 2017) and TPRX1 and TPRX2 (Zou et al. 2022) directly activate expression of DUXB in the embryo. DUXB is a double homeobox transcription factor.
Literature References
PubMed ID Title Journal Year
28459457 Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons

Peterson, CM, Lim, JW, Cairns, BR, Pflueger, C, Tapscott, SJ, Wike, CL, Grow, EJ, Hendrickson, PG, Carrell, DT, Nix, DA, Whiddon, JL, Emery, BR, Wilcox, AL, Weaver, BD, Doráis, JA

Nat Genet 2017
36074823 Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation

Li, M, Chen, ZJ, Song, J, Hou, Z, Liu, B, Tao, W, Zhang, C, Wang, L, Wu, K, Wang, Q, Kong, F, Xiong, Z, Liu, B, Wang, Q, Zhao, S, Ma, X, Zhao, H, Xie, W, Zou, Z, Lai, F, Fan, Q

Science 2022
26360614 Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development

Kere, J, Katayama, S, Sheikhi, M, Johnsson, A, Jaconi, M, Hovatta, O, Töhönen, V, Jouhilahti, EM, Vesterlund, L, Linnarsson, S, Madissoon, E, Filippini-Cattaneo, G, Bürglin, TR

Nat Commun 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
DUX4:TPRXL:TPRX1:TPRX2:DUXB gene [nucleoplasm] (Homo sapiens)
Active Unit
DUX4 [nucleoplasm]
Authored
May, B  (2022-09-26)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-10-02)
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