Expression of DUXA in the embryo

Stable Identifier
R-HSA-9817940
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The DUXA gene is transcribed to yield mRNA (Tohonen et al. 2015) which is translated to yield protein. DUXA is expressed in 4-cell embryos during the initial phase of zygotic genome activation (Tohonen et al. 2015, Hendrickson et al. 2017) but not later in the morula (Hendrickson et al. 2017). DUX4 (De Iaco et al. 2017, Hendrickson et al. 2017, Vuoristo et al. 2022) directly activates expression of DUXA, a double homeobox transcription factor. Triple knockdown of TPRXL, TPRX1, and TPRX2 reduced expression of DUXA; however, ectopic expression of TPRX1, TPRX2, and TPRXL did not activate expression (Zou et al. 2022)
Literature References
PubMed ID Title Journal Year
35402882 DUX4 is a multifunctional factor priming human embryonic genome activation

Kirjanov, I, Murakawa, Y, Katayama, S, Weltner, J, Recher, G, Nykänen, S, Johnson, MS, Huhtala, M, Lundin, K, Krjutškov, K, Otonkoski, T, Jouhilahti, EM, Paluoja, P, Hashimoto, K, Tamirat, M, Paloviita, P, Kere, J, Hydén-Granskog, C, Varjosalo, M, Tapanainen, JS, Takegami, Y, Damdimopoulos, A, Bhagat, S, Yoshihara, M, Vuoristo, S, Ranga, V, Tuuri, T, Ezer, S, Airenne, TT, Kawaji, H, Bürglin, TR, Gawriyski, L, Kanemaru, A

iScience 2022
28459456 DUX-family transcription factors regulate zygotic genome activation in placental mammals

Duc, J, De Iaco, A, Coluccio, A, Verp, S, Planet, E, Trono, D

Nat Genet 2017
28459457 Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons

Peterson, CM, Lim, JW, Cairns, BR, Pflueger, C, Tapscott, SJ, Wike, CL, Grow, EJ, Hendrickson, PG, Carrell, DT, Nix, DA, Whiddon, JL, Emery, BR, Wilcox, AL, Weaver, BD, Doráis, JA

Nat Genet 2017
36074823 Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation

Li, M, Chen, ZJ, Song, J, Hou, Z, Liu, B, Tao, W, Zhang, C, Wang, L, Wu, K, Wang, Q, Kong, F, Xiong, Z, Liu, B, Wang, Q, Zhao, S, Ma, X, Zhao, H, Xie, W, Zou, Z, Lai, F, Fan, Q

Science 2022
26360614 Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development

Kere, J, Katayama, S, Sheikhi, M, Johnsson, A, Jaconi, M, Hovatta, O, Töhönen, V, Jouhilahti, EM, Vesterlund, L, Linnarsson, S, Madissoon, E, Filippini-Cattaneo, G, Bürglin, TR

Nat Commun 2015
Participants
Participates
This event is regulated
Authored
Reviewed
Created
Cite Us!