Reactome | BTG4 binds CNOT7 of the CCR4-NOT complex, PABPN1L, and eIF4E of the mRNP

BTG4 binds CNOT7 of the CCR4-NOT complex, PABPN1L, and eIF4E of the mRNP

Stable Identifier

R-HSA-9817692

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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BTG4 binds CNOT7 of the CCR4-NOT complex, PABPN1L, and eIF4E of the mRNP

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BTG4 binds eIF4E of the mRNA-protein complex (mRNP) and CNOT7 (CAF1) and CNOT8 of the CCR4-NOT RNA deadenylase complex, thereby connecting maternal mRNPs with mRNA degradation (inferred from mouse homologs). The polyadenylate binding protein PABPN1L also mediates binding of BTG4 to mRNA (inferred from mouse homologs). In mouse oocytes lacking BTG4, shortening of mRNA polyadenylate tails, an initial step in mRNA degradation, is impaired and Btg4 KO embryos arrested at the 1-2 cell stage (Yu et al. 2016, Liu et al., 2016, Pasternak et al. 2016). Upon Btg4 siRNA knockdown, mouse oocytes precociously enter anaphase II (Pasternak et al. 2016). Of note, global deadenylation can still occur in mouse oocytes mutant for Btg4 mutant oocytes. However, BTG4 is required for selective gene de-adenylation and production of very short-tailed transcripts in mice (Xiong et al. 2022).

Literature References

PubMed ID	Title	Journal	Year
32502391	Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility Sun, X, Zhang, S, Sha, Q, Lu, G, Li, X, Fan, H, Zhao, L, Zhou, Z, Hu, L, Meng, F, Shi, J, Dai, J, Shi, R, Gong, F, Chen, B, Zheng, W, Cai, S, Fu, J, Wang, L, Lin, G, Niu, X, Sang, Q	Am J Hum Genet	2020
34647228	A novel homozygous missense variant in BTG4 causes zygotic cleavage failure and female infertility Wang, L, Li, Q, Chen, B, Zhou, Y, Wang, L, Liu, R, Zhou, Z, Jin, L, Sang, Q	J Assist Reprod Genet	2021