AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine

Stable Identifier
R-HSA-9817513
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine
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The first phase of active DNA demethylation in the male pronucleus is initiated by deamination of cytidine residues by AICDA (AID), which produces T-G mismatches that are repaired by the long patch base excision repair pathway to yield a C-G base pair (inferred from mouse homologs). If the repair patch encompasses a 5-methylcytidine residue adjacent to the T-G mismatch then the 5-methylcytidine is replaced by cytidine, resulting in a loss of DNA methylation (inferred from mouse cells).
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Catalyst Activity

cytidine deaminase activity of AICDA [nucleoplasm]

Physical Entity
AICDA [nucleoplasm] (Homo sapiens)
Activity
cytidine deaminase activity (GO:0004126)
Inferred From
Aicda deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine (Mus musculus)
Authored
May, B  (2022-09-21)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-09-23)
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