UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3

Stable Identifier
R-HSA-9817512
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3
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The cytidine deaminase AICDA, the uracil-DNA glycosylase UNG (UNG2), and base excision repair are required for removal of 5-methylcytidine from DNA in the male pronucleus of the zygote (inferred from mouse homologs in mouse zygotes). The inference is that AICDA deaminates cytidine to uridine and then UNG and the base excision repair pathway remove the uridine residue and any adjacent 5-methylcytidine residues, resynthesizing DNA with unmodified cytidine residues in their places.
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Catalyst Activity

uracil DNA N-glycosylase activity of UNG [nucleoplasm]

Physical Entity
UNG [nucleoplasm] (Homo sapiens)
Activity
uracil DNA N-glycosylase activity (GO:0004844)
Inferred From
Ung (Ung2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3 (Mus musculus)
Authored
May, B  (2022-09-21)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-09-23)
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