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DPPA3 binds histone H3K9me2 in chromatin
Stable Identifier
R-HSA-9817471
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Chromatin modifications during the maternal to zygotic transition (MZT) (Homo sapiens)
DPPA3 binds histone H3K9me2 in chromatin (Homo sapiens)
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DPPA3 (also called STELLA) binds dimethylated lysine-9 of histone H3 (H3K9me2, lysine-10 of the preprotein) that is present in the maternal genome but not the paternal genome of the zygote (inferred from mouse homologs). DPPA3 prevents TET3 from oxidizing 5-methylcytidine to 5-hydroxymethylcytidine and thereby blocks one pathway of active DNA methylation in the female pronucleus (inferred from mouse zygotes).
Participants
Input
Chromatin with H3K9me2, 5mC [nucleoplasm]
(Homo sapiens)
DPPA3 [nucleoplasm]
(Homo sapiens)
Output
Chromatin with DPPA3:H3K9me2 and 5mC [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Chromatin modifications during the maternal to zygotic transition (MZT) (Homo sapiens)
Inferred From
Dppa3 binds histone H3K9me2 in chromatin (Mus musculus)
Authored
May, B (2022-09-18)
Reviewed
Xie, W (2023-08-08)
Created
May, B (2022-09-21)
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