Factor H binds to membrane-associated C3b

Stable Identifier
R-HSA-981728
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Factor H binds to membrane-associated C3b
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Factor H (CFH) regulates the alternative pathway C3 convertase C3bBb and its C3b component both in plasma and at host cell surfaces. CFH binds to membrane-associated C3b, competing with Factor B and thereby preventing formation of the active C3 convertase C3bBb. In addition, it acts as a cofactor for the Factor I-mediated proteolytic inactivation of C3b to iC3b.
Literature References
PubMed ID Title Journal Year
1067618 Control of the amplification convertase of complement by the plasma protein beta1H

Weiler, JM, Fearon, DT, Daha, MR, Austen, KF

Proc Natl Acad Sci U S A 1976
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CFH:Host cell surface [plasma membrane] (Homo sapiens)
Orthologous Events
Complement factor H binds to surface-bound C3b (Gallus gallus)
Factor H binds to membrane-associated C3b (Bos taurus)
Factor H binds to membrane-associated C3b (Canis familiaris)
Factor H binds to membrane-associated C3b (Danio rerio)
Factor H binds to membrane-associated C3b (Gallus gallus)
Factor H binds to membrane-associated C3b (Sus scrofa)
Factor H binds to membrane-associated C3b (Xenopus tropicalis)
Authored
Jupe, S  (2010-10-26)
Reviewed
Fraczek, LA  (2012-02-13)
Bradley, DT  (2012-02-13)
Created
Jupe, S  (2010-10-26)
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