Factor H binds to membrane-associated C3b

Stable Identifier
R-HSA-981728
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Factor H (CFH) regulates the alternative pathway C3 convertase C3bBb and its C3b component both in plasma and at host cell surfaces. CFH binds to membrane-associated C3b, competing with Factor B and thereby preventing formation of the active C3 convertase C3bBb. In addition, it acts as a cofactor for the Factor I-mediated proteolytic inactivation of C3b to iC3b.

Literature References
PubMed ID Title Journal Year
1067618 Control of the amplification convertase of complement by the plasma protein beta1H

Weiler, JM, Daha, MR, Austen, KF, Fearon, DT

Proc Natl Acad Sci U S A 1976
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