C4b binding protein displaces C2a

Stable Identifier
R-HSA-981680
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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C4b binding protein displaces C2a
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C4 binding protein accelerates the decay of C4bC2a in a dose-dependent fashion. The mechanism of this is poorly understood, but is distinct from Factor I mediated degradation of C4b and believed to represent the displacement of C2a from specific binding sites on C4b (Gigli et al. 1979).

Literature References
PubMed ID Title Journal Year
293746 Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator

Gigli, I, Fujita, T, Nussenzweig, V

Proc Natl Acad Sci U S A 1979
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Authored
Jupe, S  (2010-10-26)
Reviewed
Fraczek, LA  (2012-02-13)
Bradley, DT  (2012-02-13)
Created
Jupe, S  (2010-10-26)
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