DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene

Stable Identifier
R-HSA-9816396
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene
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DUX4 binds four sites in the upstream promoter and enhancer region of ZSCAN4 (Geng et al. 2012, De Iaco et al. 2017) and a site in the second exon of the ZSCAN4 gene (Choi et al. 2016) and recruits EP300 (p300) and CREBBP (CBP) (Choi et al. 2016, Vuoristo et al. 2022). DUX4 activates bidirectional transcription of an ERVL-MaLR retrotransposon element 20 kb upstream of the ZSCAN4 transcription start site that upregulates expression of ZSCAN4 (Vuoristo et al. 2022). TPRXL, TPRX1, and TPRX2 are translated at the time of zygotic genome activation and TPRX1 and TPRX2 bind and activate the ZSCAN4 gene (Zou et al. 2022). In mouse, Obox genes appear to be orthologous to human TPRX2 (Maeso et al. 2016) and bind and activate mouse Zscan4 genes (Ji et al. 2023).
Literature References
PubMed ID Title Journal Year
35402882 DUX4 is a multifunctional factor priming human embryonic genome activation

Vuoristo, S, Bhagat, S, Hydén-Granskog, C, Yoshihara, M, Gawriyski, L, Jouhilahti, EM, Ranga, V, Tamirat, M, Huhtala, M, Kirjanov, I, Nykänen, S, Krjutškov, K, Damdimopoulos, A, Weltner, J, Hashimoto, K, Recher, G, Ezer, S, Paluoja, P, Paloviita, P, Takegami, Y, Kanemaru, A, Lundin, K, Airenne, TT, Otonkoski, T, Tapanainen, JS, Kawaji, H, Murakawa, Y, Bürglin, TR, Varjosalo, M, Johnson, MS, Tuuri, T, Katayama, S, Kere, J

iScience 2022
28459456 DUX-family transcription factors regulate zygotic genome activation in placental mammals

De Iaco, A, Planet, E, Coluccio, A, Verp, S, Duc, J, Trono, D

Nat Genet 2017
36074823 Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation

Zou, Z, Zhang, C, Wang, Q, Hou, Z, Xiong, Z, Kong, F, Wang, Q, Song, J, Liu, B, Liu, B, Wang, L, Lai, F, Fan, Q, Tao, W, Zhao, S, Ma, X, Li, M, Wu, K, Zhao, H, Chen, ZJ, Xie, W

Science 2022
26951377 DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes

Choi, SH, Gearhart, MD, Cui, Z, Bosnakovski, D, Kim, M, Schennum, N, Kyba, M

Nucleic Acids Res 2016
22209328 DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy

Geng, LN, Yao, Z, Snider, L, Fong, AP, Cech, JN, Young, JM, van der Maarel, SM, Ruzzo, WL, Gentleman, RC, Tawil, R, Tapscott, SJ

Dev Cell 2012
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Inferred From
Dux binds a Zscan4 gene (Mus musculus)
Authored
May, B  (2022-09-07)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-09-12)
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