Complement factor I inactivates C4BP-bound C4b

Stable Identifier
R-HSA-981637
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Complement factor I inactivates C4BP-bound C4b
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

C4b-binding protein is a cofactor in Factor I mediated C4b proteolysis. C4b is cleaved, releasing C4c, leaving C4d bound to the cell surface.

Literature References
PubMed ID Title Journal Year
1386357 Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46)

Masaki, T, Matsumoto, M, Nakanishi, I, Yasuda, R, Seya, T

J Biochem 1992
Participants
Input
Output
Participant Of
hasEvent
Authored
Jupe, S  (2010-10-26)
Reviewed
Bradley, DT  (2012-02-13)
Fraczek, LA  (2012-02-13)
Created
Jupe, S  (2010-10-26)
Cite Us!