Complement factor I inactivates C4BP-bound C4b

Stable Identifier
R-HSA-981637
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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Complement factor I inactivates C4BP-bound C4b
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C4b-binding protein is a cofactor in Factor I mediated C4b proteolysis. C4b is cleaved, releasing C4c, leaving C4d bound to the cell surface.

Literature References
PubMed ID Title Journal Year
1386357 Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46)

Masaki, T, Matsumoto, M, Nakanishi, I, Yasuda, R, Seya, T

J Biochem 1992
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Orthologous Events
Complement factor I inactivates C4BP-bound C4b (Bos taurus)
Complement factor I inactivates C4BP-bound C4b (Danio rerio)
Complement factor I inactivates C4BP-bound C4b (Mus musculus)
Complement factor I inactivates C4BP-bound C4b (Rattus norvegicus)
Complement factor I inactivates C4BP-bound C4b (Sus scrofa)
Authored
Jupe, S  (2010-10-26)
Reviewed
Bradley, DT  (2012-02-13)
Fraczek, LA  (2012-02-13)
Created
Jupe, S  (2010-10-26)