Complement factor I inactivates C4BP-bound C4b

Stable Identifier
R-HSA-981637
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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Complement factor I inactivates C4BP-bound C4b
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C4b-binding protein is a cofactor in Factor I mediated C4b proteolysis. C4b is cleaved, releasing C4c, leaving C4d bound to the cell surface.

Literature References
PubMed ID Title Journal Year
1386357 Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46)

Matsumoto, M, Yasuda, R, Nakanishi, I, Seya, T, Masaki, T

J Biochem 1992
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Authored
Jupe, S  (2010-10-26)
Reviewed
Fraczek, LA  (2012-02-13)
Bradley, DT  (2012-02-13)
Created
Jupe, S  (2010-10-26)
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