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NFYC [nucleoplasm]
Stable Identifier
R-HSA-981546
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NF-YC, Nuclear transcription factor Y subunit gamma, NFYC_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)
Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of XBP1(S) (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell death genes (Homo sapiens)
BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y (Homo sapiens)
FOXO1,FOXO3,(FOXO4):NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter (Homo sapiens)
FOXO1,FOXO3,(FOXO4):NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
SREBP1A,2:NF-Y:HMGCR gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of 7-Dehydrocholesterol Reductase (DHCR7) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:DHCR7 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)
SREBP1A,1C,2:NF-Y:FDPS gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Fatty Acid Synthase (FASN) (Homo sapiens)
SREBP1A,1C:NF-Y:SP1:FASN gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:GGPS1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) (Homo sapiens)
SREBP1A,1C:NF-Y:GPAM gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:IDI1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Lanosterol Demethylase (CYP51A1) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:CYP51A1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Lathosterol Oxidase (SC5D, SC5DL) (Homo sapiens)
SREBP1A,2:NF-Y:SC5DL gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Mevalonate Kinase (MVK) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:MVK gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Phosphomevalonate Kinase (PMVK) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:PMVK gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Squalene Monooxygenase (SQLE) (Homo sapiens)
SREBP1A,2:SQLE gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of TM7SF2 (Homo sapiens)
SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C binds the FASN promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C:NF-Y:SP1:FASN gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C binds the GPAM promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C:NF-Y:GPAM gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the FDFT1 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the FDPS promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:FDPS gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the HMGCS1 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the TM7SF2 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the CYP51A1 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:CYP51A1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the DHCR7 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:DHCR7 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the GGPS1 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:GGPS1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the HMGCR promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:HMGCR gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the IDI1 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:IDI1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the MVK promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:MVK gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the PMVK promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:PMVK gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the SC5DL promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SC5DL gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the SQLE promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
SREBP1A,2:SQLE gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
SREBP1A,2:NF-Y:HMGCR gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYC [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13952 NFYC
Gene Names
NFYC
Chain
chain:1-458
Reference Genes
BioGPS Gene:4802 NFYC
COSMIC (genes):NFYC NFYC
CTD Gene:4802 NFYC
dbSNP Gene:4802 NFYC
ENSEMBL:ENSG00000066136 NFYC
ENSEMBL_homo_sapiens_GENE:ENSG00000066136.21 NFYC
HGNC:7806 NFYC
KEGG Gene (Homo sapiens):4802 NFYC
Monarch:4802 NFYC
NCBI Gene:4802 NFYC
OMIM:605344 NFYC
UCSC:Q13952 NFYC
Reference Transcript
RefSeq:NM_001142587.1 NFYC
RefSeq:XM_006710658.2 NFYC
RefSeq:XM_017001367.1 NFYC
RefSeq:XM_005270895.3 NFYC
RefSeq:XM_017001365.1 NFYC
RefSeq:XM_011541516.1 NFYC
RefSeq:XM_005270894.1 NFYC
RefSeq:NM_014223.4 NFYC
RefSeq:XM_006710662.2 NFYC
RefSeq:NM_001308115.1 NFYC
RefSeq:NM_001308114.1 NFYC
RefSeq:XM_006710661.1 NFYC
RefSeq:NM_001142590.1 NFYC
RefSeq:NM_001142589.1 NFYC
RefSeq:XM_017001369.1 NFYC
RefSeq:XM_006710660.2 NFYC
RefSeq:NM_001142588.1 NFYC
RefSeq:XM_017001368.1 NFYC
Other Identifiers
11724873_x_at
11739082_x_at
11742119_a_at
11742120_x_at
11750465_x_at
11754671_s_at
1559218_PM_s_at
1559218_s_at
202215_PM_s_at
202215_s_at
202216_PM_x_at
202216_x_at
211251_PM_x_at
211251_x_at
211797_PM_s_at
211797_s_at
2332014
2332015
2332016
2332017
2332020
2332023
2332026
2332027
2332032
2332033
2332034
2332036
2332040
2332045
2332046
2332047
2332048
2332051
2332055
2332056
2332060
2332062
2332067
2332070
2332071
2332072
2332073
2332074
2332078
2332080
2332081
3213229
3213232
40466_at
4802
7900468
A_14_P121677
A_23_P22994
A_24_P165346
A_33_P3363665
A_33_P3363674
A_33_P3368706
D85425_s_at
GE55450
GE80428
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006351
GO:0006355
GO:0006357
GO:0006457
GO:0016602
GO:0032993
GO:0035065
GO:0036211
GO:0043226
GO:0043229
GO:0045893
GO:0045944
GO:0046982
GO:0090575
GO:0140110
HMNXSV003028741
HMNXSV003047833
ILMN_1810488
PH_hs_0023479
TC01004337.hg
Z74792_s_at
g11496977_3p_a_at
g13436472_3p_s_at
g1669493_3p_a_at
Participates
as a component of
NF-Y [nucleoplasm] (Homo sapiens)
Inferred To
HAP5 [nucleoplasm]
(Saccharomyces cerevisiae)
nfyc-1 [nucleoplasm]
(Caenorhabditis elegans)
Nfyc [nucleoplasm]
(Mus musculus)
Nfyc [nucleoplasm]
(Rattus norvegicus)
NFYC [nucleoplasm]
(Bos taurus)
NFYC [nucleoplasm]
(Canis familiaris)
NFYC [nucleoplasm]
(Dictyostelium discoideum)
NFYC [nucleoplasm]
(Gallus gallus)
NFYC [nucleoplasm]
(Sus scrofa)
Nf-YC [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_055038.2
,
NP_001295043.1
,
XP_006710723.2
,
XP_016856858.1
,
NP_001136061.1
,
XP_006710724.1
,
XP_016856856.1
,
XP_011539818.1
,
XP_005270952.3
,
XP_016856857.1
,
NP_001295044.1
,
XP_006710721.2
,
NP_001136059.1
,
NP_001136060.1
,
XP_006710725.2
,
XP_016856854.1
,
NP_001136062.1
,
XP_005270951.1
OpenTargets
ENSG00000066136
HPA
ENSG00000066136-NFYC
GeneCards
Q13952
Ensembl
ENST00000372653
,
ENST00000372654
,
ENSG00000066136
,
ENSP00000361734
,
ENSP00000361738
,
ENSP00000361737
,
ENSP00000414299
,
ENSP00000396620
,
ENST00000372652
,
ENSP00000361736
,
ENST00000372651
,
ENST00000447388
,
ENST00000440226
,
ENST00000456393
,
ENSP00000404427
,
ENSP00000408315
,
ENSP00000408867
,
ENSP00000312617
,
ENST00000427410
,
ENST00000425457
,
ENST00000308733
PRO
Q13952
Pharos - Targets
Q13952
PDB
4CSR
,
7AH8
,
1N1J
,
6QMP
,
6QMS
,
6QMQ
,
4AWL
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