ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position

Stable Identifier
R-HSA-981497
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
ReviewStatus
5/5
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ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position
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The human genes ST3GAL1-4 encode for sialyltransferases1-4 respectively (Shang et al. 1999, Kim et al. 1996, Kitagawa & Paulson 1993, Basu et al. 1993). They add silaic acid (Neu5Ac) onto the T antigen forming an alpha-3-sialyl O-glycan.
Literature References
PubMed ID Title Journal Year
8920913 Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II)

Lee, YC, Kim, CH, Kim, YJ, Tsuji, S, Kim, KS, Choe, IS, Kim, SH, Ko, JH

Biochem Biophys Res Commun 1996
8611500 Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line

Basu, S, Basu, M, Li, Z, Basu, SS

Biochemistry 1996
8333853 Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase

Kitagawa, H, Paulson, JC

Biochem Biophys Res Commun 1993
10504389 Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver

Ding, H, Qiu, R, Liu, J, Jin, C, Yang, S, Shang, J, Zhou, R, Zhang, S, Wang, J

Eur J Biochem 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL1-4 [Golgi membrane]

Physical Entity
ST3GAL1-4 [Golgi membrane] (Homo sapiens)
Activity
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity (GO:0003836)
Orthologous Events
ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Bos taurus)
ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Canis familiaris)
ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Danio rerio)
ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Gallus gallus)
ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Mus musculus)
ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Rattus norvegicus)
ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Sus scrofa)
ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Xenopus tropicalis)
Authored
Jassal, B  (2010-10-15)
Reviewed
Ferrer, A  (2011-11-04)
Created
Jassal, B  (2010-10-21)
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