ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position

Stable Identifier
R-HSA-981497
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The human genes ST3GAL1-4 encode for sialyltransferases1-4 respectively (Shang et al. 1999, Kim et al. 1996, Kitagawa & Paulson 1993, Basu et al. 1993). They add silaic acid (Neu5Ac) onto the T antigen forming an alpha-3-sialyl O-glycan.

Literature References
PubMed ID Title Journal Year
8611500 Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line

Basu, SS, Basu, M, Li, Z, Basu, S

Biochemistry 1996
8920913 Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II)

Kim, YJ, Kim, KS, Kim, SH, Kim, CH, Ko, JH, Choe, IS, Tsuji, S, Lee, YC

Biochem Biophys Res Commun 1996
8333853 Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase

Kitagawa, H, Paulson, JC

Biochem Biophys Res Commun 1993
10504389 Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver

Shang, J, Qiu, R, Wang, J, Liu, J, Zhou, R, Ding, H, Yang, S, Zhang, S, Jin, C

Eur J Biochem 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL1-4 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created