Reactome | ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position

ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position

Stable Identifier

R-HSA-981497

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human genes ST3GAL1-4 encode for sialyltransferases1-4 respectively (Shang et al. 1999, Kim et al. 1996, Kitagawa & Paulson 1993, Basu et al. 1993). They add silaic acid (Neu5Ac) onto the T antigen forming an alpha-3-sialyl O-glycan.

Literature References

PubMed ID	Title	Journal	Year
8920913	Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II) Kim, YJ, Kim, KS, Kim, SH, Kim, CH, Ko, JH, Choe, IS, Tsuji, S, Lee, YC	Biochem Biophys Res Commun	1996
8611500	Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line Basu, SS, Basu, M, Li, Z, Basu, S	Biochemistry	1996
8333853	Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase Kitagawa, H, Paulson, JC	Biochem Biophys Res Commun	1993
10504389	Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver Shang, J, Qiu, R, Wang, J, Liu, J, Zhou, R, Ding, H, Yang, S, Zhang, S, Jin, C	Eur J Biochem	1999