Reactome | ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position

ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position

Stable Identifier

R-HSA-981497

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position

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The human genes ST3GAL1-4 encode for sialyltransferases1-4 respectively (Shang et al. 1999, Kim et al. 1996, Kitagawa & Paulson 1993, Basu et al. 1993). They add silaic acid (Neu5Ac) onto the T antigen forming an alpha-3-sialyl O-glycan.

Literature References

PubMed ID	Title	Journal	Year
8920913	Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II) Lee, YC, Kim, CH, Kim, YJ, Tsuji, S, Kim, KS, Choe, IS, Kim, SH, Ko, JH	Biochem Biophys Res Commun	1996
8611500	Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line Basu, S, Basu, M, Li, Z, Basu, SS	Biochemistry	1996
8333853	Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase Kitagawa, H, Paulson, JC	Biochem Biophys Res Commun	1993
10504389	Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver Ding, H, Qiu, R, Liu, J, Jin, C, Yang, S, Shang, J, Zhou, R, Zhang, S, Wang, J	Eur J Biochem	1999