AcK-NFE2L2 binds the BCL2L1 gene

Stable Identifier
R-HSA-9796084
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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AcK-NFE2L2 binds the BCL2L1 gene
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NFE2L2 in control of BCL2L1 expression and apoptotic cell death with implications in antioxidant protection, survival of cancer cells, and drug resistance. Promoter mutagenesis, transfection, and chromatin immunoprecipitation assays identified an ARE between nucleotides -608 and -600 in the forward strand of the proximal BCL2L1 promoter that bound to NFE2L2 and led to increased BCL2L1 gene expression (Niture et al, 2013)
Literature References
PubMed ID Title Journal Year
23275004 Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance

Niture, SK, Jaiswal, AK

Free Radic Biol Med 2013
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Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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