EIF2AK3 phosphorylates NFE2L2

Stable Identifier
R-HSA-9796081
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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EIF2AK3 phosphorylates NFE2L2
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EIF2AK3 directly phosphorylates NFE2L2 and induces dissociation of KEAP1 from NFE2L2 thus inducing nuclear transport (Cullinan et al, 2003). This observation is primarily in mice but this regulation significance is well-reported in human diseases like AML (Jang et al, 2020).
Literature References
PubMed ID Title Journal Year
32293500 PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells

Cheong, JW, Kim, JS, Chung, H, Jeung, HK, Eom, JI, Jang, JE, Min, YH, Kim, YR

J Exp Clin Cancer Res 2020
14517290 Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

Kaufman, RJ, Zhang, D, Arvisais, E, Hannink, M, Diehl, JA, Cullinan, SB

Mol Cell Biol 2003
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Catalyst Activity

protein serine/threonine kinase activity of EIF2AK3 [endoplasmic reticulum membrane]

Physical Entity
EIF2AK3 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Eif2ak3 phosphorylates Nfe2l2 (Mus musculus)
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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