NFE2L2 dependent ABCC3 expression

Stable Identifier
R-HSA-9796079
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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NFE2L2 dependent ABCC3 expression
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ABCC3 is under transcriptional control of NFE2L2 and contains a functional antioxidant response element within the eighth intron of the human ABCC3 gene (Canet et al, 2015; Pellegatta et al, 2019). It plays a significant role in multidrug resistance.
Literature References
PubMed ID Title Journal Year
25349122 Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene

Yamamoto, M, Zhang, DD, Canet, MJ, Jackson, JP, Wu, T, Merrell, MD, Cherrington, NJ, Lickteig, AJ, Maher, JM, Harder, BG

Drug Metab Dispos 2015
31771235 ABCC3 Expressed by CD56dim CD16+ NK Cells Predicts Response in Glioblastoma Patients Treated with Combined Chemotherapy and Dendritic Cell Immunotherapy

Paterra, R, Anghileri, E, Pessina, S, Finocchiaro, G, Di Ianni, N, Eoli, M, Pellegatta, S

Int J Mol Sci 2019
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NEF2L2:ABCC3gene complex [nucleoplasm] (Homo sapiens)
Active Unit
p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm]
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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