NFE2L2 dependent ATF4 expression

Stable Identifier
R-HSA-9796061
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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NFE2L2 dependent ATF4 expression
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Stress induction of ATF4 is significantly regulated transcriptionally through an NFE2L2-dependent mechanism. This helps in regulating the oxidative stress impact (Miyamoto et al, 2011, DeNicola et al, 2015)
Literature References
PubMed ID Title Journal Year
26482881 NRF2 regulates serine biosynthesis in non-small cell lung cancer

Huffman, KE, Hu, Z, Sudderth, JA, Xie, Y, Tang, H, Wu, D, Mullarky, E, DeBerardinis, RJ, DeNicola, GM, Chen, PH, Cantley, LC, Wistuba, II, Minna, JD, Asara, JM

Nat Genet 2015
21087962 Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells

Tawara, A, Kohno, K, Bin, H, Izumi, H, Miyamoto, N, Sasaguri, Y, Kondo, H, Miyamoto, R

Invest Ophthalmol Vis Sci 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NFE2L2:ATF4 gene complex [nucleoplasm] (Homo sapiens)
Active Unit
p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm]
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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