NFkB binds the NFE2L2 gene

Stable Identifier
R-HSA-9796056
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NFkB binds the NFE2L2 gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
High Levels of nuclear NFE2L2 expressions are regulated by high levels of nuclear NFkB in AML cells. The presence of the κB2 site, located at +270 upstream of the transcription start site, is responsible for the increased expression of NFE2L2 seen in AML cells. (Rushworth et al, 2012)
Literature References
PubMed ID Title Journal Year
23077289 The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance

Zaitseva, L, Murray, MY, Rushworth, SA, MacEwan, DJ, Bowles, KM, Shah, NM

Blood 2012
Participants
Input
Output
Participates
as an event of
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
Cite Us!