PRKCI phosphorylates NFE2L2

Stable Identifier
R-HSA-9796053
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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PRKCI phosphorylates NFE2L2
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Phosphorylation of NFE2L2 Ser40 by PRKCI (PKC iota, an atypical PKC) is involved in the nuclear translocation and ARE transactivation of NFE2L2 by oxidative stress (Numazawa et al, 2003)
Literature References
PubMed ID Title Journal Year
12700136 Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress

Numazawa, S, Yoshida, A, Ishikawa, M, Tanaka, S, Yoshida, T

Am J Physiol Cell Physiol 2003
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Output
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as an event of
Catalyst Activity

diacylglycerol-dependent serine/threonine kinase activity of PRKCI [cytosol]

Physical Entity
PRKCI [cytosol] (Homo sapiens)
Activity
diacylglycerol-dependent serine/threonine kinase activity (GO:0004697)
Orthologous Events
PRKCI phosphorylates NFE2L2 (Bos taurus)
PRKCI phosphorylates NFE2L2 (Caenorhabditis elegans)
PRKCI phosphorylates NFE2L2 (Canis familiaris)
PRKCI phosphorylates NFE2L2 (Danio rerio)
PRKCI phosphorylates NFE2L2 (Drosophila melanogaster)
PRKCI phosphorylates NFE2L2 (Gallus gallus)
PRKCI phosphorylates NFE2L2 (Mus musculus)
PRKCI phosphorylates NFE2L2 (Rattus norvegicus)
PRKCI phosphorylates NFE2L2 (Sus scrofa)
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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