AcK-NFE2L2 binds the KEAP1 gene

Stable Identifier
R-HSA-9796050
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
3/5
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NFE2L2 (NRF2) controls its own degradation by regulating the expression and induction of the INrf2 (KEAP1) gene. The antioxidant treatment of cells led to nuclear localization and stabilization of Nrf2 and induction of INrf2 gene expression (PMID: 17925401)
Literature References
PubMed ID Title Journal Year
17925401 An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance

Papusha, V, Jain, AK, Lee, OH, Jaiswal, AK

J Biol Chem 2007
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