AcK-NFE2L2 binds the ABCG2 gene

Stable Identifier
R-HSA-9796048
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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AcK-NFE2L2 binds the ABCG2 gene
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A detailed promoter analysis using luciferase reporter assays showed that ARE at -431 to -420 bp is critical for the NFE2L2-mediated expression in lung cancer cells. Electrophoretic mobility shift assays and chromatin immunoprecipitation assays revealed that NFE2L2 interacts with the ABCG2 ARE element at -431 to -420 bp in vitro and in vivo (Singh et al, 2010)
Literature References
PubMed ID Title Journal Year
20682644 Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype

Wu, H, Singh, A, Biswal, S, Zhang, P, Happel, C, Ma, J

Mol Cancer Ther 2010
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Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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