PRKAA2 regulated nuclear export of NFE2L2

Stable Identifier
R-HSA-9796047
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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PRKAA2 regulated nuclear export of NFE2L2
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PRKAA2 phosphorylates NFE2L2 at the Ser558 residue (Ser550 in mouse) which is located in the canonical nuclear export signal leading to inhibition of NFE2L2 nuclear transport and enhanced nuclear retention. (Joo et al, 2016)
Literature References
PubMed ID Title Journal Year
27161318 AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

Lee, KY, Koo, JH, Kim, WD, Kim, JH, Kim, SG, Joo, MS

Mol Cell Biol 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
p-S,T,S558-NFE2L2 [nucleoplasm] (Homo sapiens)
Orthologous Events
PRKAA2 regulated nuclear export of NFE2L2 (Bos taurus)
PRKAA2 regulated nuclear export of NFE2L2 (Caenorhabditis elegans)
PRKAA2 regulated nuclear export of NFE2L2 (Canis familiaris)
PRKAA2 regulated nuclear export of NFE2L2 (Danio rerio)
PRKAA2 regulated nuclear export of NFE2L2 (Drosophila melanogaster)
PRKAA2 regulated nuclear export of NFE2L2 (Gallus gallus)
PRKAA2 regulated nuclear export of NFE2L2 (Mus musculus)
PRKAA2 regulated nuclear export of NFE2L2 (Rattus norvegicus)
PRKAA2 regulated nuclear export of NFE2L2 (Sus scrofa)
PRKAA2 regulated nuclear export of NFE2L2 (Xenopus tropicalis)
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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