NFE2L2 dependent TXN expression

Stable Identifier
R-HSA-9796045
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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NFE2L2 dependent TXN expression
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NFE2L2 regulates the expression of TXN (Thioredoxin) by binding to ARE element present on TXN promoter and regulating anti-oxidant response (Hawkes et al, 2014; Tanito et al, 2005; Kim et al, 2001).
Literature References
PubMed ID Title Journal Year
24041992 Regulation of the human thioredoxin gene promoter and its key substrates: a study of functional and putative regulatory elements

Hawkes, HJ, Karlenius, TC, Tonissen, KF

Biochim Biophys Acta 2014
15728556 Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice

Tanito, M, Masutani, H, Kim, YC, Nishikawa, M, Ohira, A, Yodoi, J

Invest Ophthalmol Vis Sci 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TXN gene:p-AcK-NFE2L2:CREBBP,EP300:MAFK [nucleoplasm] (Homo sapiens)
Active Unit
p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm]
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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