NFE2L2 dependent TXN expression

Stable Identifier
R-HSA-9796045
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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NFE2L2 dependent TXN expression
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NFE2L2 regulates the expression of TXN (Thioredoxin) by binding to ARE element present on TXN promoter and regulating anti-oxidant response (Hawkes et al, 2014; Tanito et al, 2005; Kim et al, 2001).
Literature References
PubMed ID Title Journal Year
24041992 Regulation of the human thioredoxin gene promoter and its key substrates: a study of functional and putative regulatory elements

Karlenius, TC, Tonissen, KF, Hawkes, HJ

Biochim Biophys Acta 2014
15728556 Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice

Tanito, M, Yodoi, J, Masutani, H, Ohira, A, Nishikawa, M, Kim, YC

Invest Ophthalmol Vis Sci 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TXN gene:p-AcK-NFE2L2:CREBBP,EP300:MAFK [nucleoplasm] (Homo sapiens)
Active Unit
p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm]
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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