NFE2L2 dependent KEAP1 expression

Stable Identifier
R-HSA-9796040
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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NFE2L2 dependent KEAP1 expression
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NFE2L2 (NRF2) controls its own degradation by regulating the expression and induction of the INrf2 (KEAP1) gene. The antioxidant treatment of cells led to nuclear localization and stabilization of Nrf2 and induction of INrf2 gene expression (PMID: 17925401)
Literature References
PubMed ID Title Journal Year
17925401 An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance

Papusha, V, Jain, AK, Lee, OH, Jaiswal, AK

J Biol Chem 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NFE2L2:KEAP1 gene complex [nucleoplasm] (Homo sapiens)
Active Unit
p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm]
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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