Cipro is sulfonated to sulfo-Cipro

Stable Identifier
R-HSA-9795134
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Cipro is sulfonated to sulfo-Cipro
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Sulfociprofloxacin (sulfo-Cipro) appears as major metabolite of ciprofloxacin (Cipro) in faeces. The responsible enzymes are probably hepatic sulfotransferases (SULT) which act on the intermediate N4-hydroxyciprofloxacin, which itself is a probable biotransformation product of Cipro, catalyzed by a hepatic cytochrome P450 (reviewed by Bolledulla et al, 2014 and Sörgel, 1989; human sulfotransferases are reviewed in Gamage et al, 2006).
Literature References
PubMed ID Title Journal Year
16322073 Human Sulfotransferases and Their Role in Chemical Metabolism

Martin, JL, Barnett, A, McManus, ME, Duggleby, RG, Windmill, KF, Hempel, N, Gamage, N

Toxicol Sci 2006
2549606 Metabolism of gyrase inhibitors

Sörgel, F

Rev Infect Dis 1989
24909234 Biotransformation and bioactivation reactions of alicyclic amines in drug molecules

Worboys, P, Bourdet, DL, Bolleddula, J, Brassil, PJ, Driscoll, JP, DeMent, K

Drug Metab Rev 2014
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Authored
Stephan, R  (2022-07-28)
Reviewed
Thorn, CF  (2022-11-09)
Created
Stephan, R  (2022-07-28)
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