Reactome | SLC22A1 transports Cipro into renal cell

SLC22A1 transports Cipro into renal cell

Stable Identifier

R-HSA-9794523

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, basolateral plasma membrane, cytosol

ReviewStatus

5/5

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SLC22A1 transports Cipro into renal cell

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Because of its high renal clearance, ciprofloxacin (Cipro) is probably not reabsorbed by renal tubular cells. In addition to glomerular secretion, Cipro is also secreted contraluminally by tubular cells (reviewed by Sörgel & Kinzig, 1993). The first step of contraluminal tubular secretion consists of facilitated transport of Cipro by SLC22A1 (OCT1) through the basolateral parts of the membrane (Mulgaonkar et al, 2013). In rat, facilitated basolateral transport by Slc47a1 (rMATE1) has been shown (Ohta et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
8383921	Pharmacokinetics of gyrase inhibitors, Part 2: Renal and hepatic elimination pathways and drug interactions Kinzig, M, Sörgel, F	Am J Med	1993
23545524	Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials Gründemann, D, Venitz, J, Mulgaonkar, A, Sweet, DH	Antimicrob Agents Chemother	2013