Reactome | ALB binds Cipro

ALB binds Cipro

Stable Identifier

R-HSA-9794444

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Distribution and free concentration of various drugs can be significantly altered as a result of their binding to serum albumin (ALB). About 20 per cent of plasma ciprofloxacin (Cipro) is bound to protein (Joos et al, 1985; reviewed by Wolfson & Hooper, 1991). Cipro binds to ALB in a pH dependent manner. Slight pH variations in different extracellular environments may affect Cipro-ALB interaction (Ahmad et al, 2006; Anand et al, 2012; Varshney et al, 2014). As shown in experiments with bovine albumin, ALB undergoes significant changes in its secondary structure during the interaction (Paul et al, 2017; Ipte et al, 2019).

Literature References

PubMed ID	Title	Journal	Year
1864287	Pharmacokinetics of quinolones: newer aspects Hooper, DC, Wolfson, JS	Eur J Clin Microbiol Infect Dis	1991
24913236	Analysis of binding interaction between antibacterial ciprofloxacin and human serum albumin by spectroscopic techniques Varshney, A, Zaidi, N, Badr, G, Alam, P, Khan, RH, Ansari, Y, Ahmad, E	Cell Biochem Biophys	2014
16602760	Effect of albumin conformation on the binding of ciprofloxacin to human serum albumin: a novel approach directly assigning binding site Parveen, S, Khan, RH, Ahmad, B	Biomacromolecules	2006
22354288	Deciphering the role of pH in the binding of ciprofloxacin hydrochloride to bovine serum albumin Kurup, L, Mukherjee, S, Anand, U	Phys Chem Chem Phys	2012
28505497	Binding of ciprofloxacin to bovine serum albumin: Photophysical and thermodynamic aspects Bhattacharya, SC, Paul, BK, Guchhait, N	J Photochem Photobiol B	2017
31323489	Spectro-electrochemistry of ciprofloxacin and probing its interaction with bovine serum albumin Sahoo, S, Satpati, AK, Ipte, PR	Bioelectrochemistry	2019
3158274	Comparison of high-pressure liquid chromatography and bioassay for determination of ciprofloxacin in serum and urine Bettex, JD, Joos, B, Lüthy, R, Flepp, M, Ledergerber, B, Siegenthaler, W	Antimicrob Agents Chemother	1985