Reactome | Basolateral transport of Cipro to extracellular space

Basolateral transport of Cipro to extracellular space

Stable Identifier

R-HSA-9794414

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region

ReviewStatus

5/5

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Basolateral transport of Cipro to extracellular space

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Basolateral efflux of Cipro zwitterion is a process that needs to be helped by membrane transport proteins, as diffusion of the polar molecule through the plasma membrane is unlikely. When cytosolic concentrations are high Cipro zwitterion is transported by an unknown protein through the basolateral membrane. Membrane transporters of the major facilitator type act in response to chemiosmotic gradients. The facilitator SLCO2B1 (OATP2B1) is localized in basolateral membranes of jejunum epithelial cells and is a possible candidate for catalyzing the basolateral efflux of Cipro from epithelial cells (Keiser et al, 2017; Chen et al, 2020).

Literature References

PubMed ID	Title	Journal	Year
32114507	Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions Chen, M, Hu, S, Li, Y, Gibson, AA, Fu, Q, Baker, SD, Sparreboom, A	Drug Metab Dispos	2020
28408210	The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers Keiser, M, Kaltheuner, L, Wildberg, C, Müller, J, Grube, M, Partecke, LI, Heidecke, CD, Oswald, S	J Pharm Sci	2017