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HC-ABCG2 [apical plasma membrane]
Stable Identifier
R-HSA-9794401
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
apical plasma membrane
Synonyms
ABCG2
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Ciprofloxacin ADME (Homo sapiens)
ABCG2 transports Cipro from hepatic cell to extracellular space (Homo sapiens)
ABCG2 tetramer [apical plasma membrane] (Homo sapiens)
HC-ABCG2 [apical plasma membrane] (Homo sapiens)
ABCG2 transports Cipro from intestinal cell to extracellular space (Homo sapiens)
ABCG2 tetramer [apical plasma membrane] (Homo sapiens)
HC-ABCG2 [apical plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UNQ0 ABCG2
Gene Names
ABCG2, ABCP, BCRP, BCRP1, MXR
Chain
chain:1-655
Reference Genes
BioGPS Gene:9429 ABCG2
COSMIC (genes):ABCG2 ABCG2
CTD Gene:9429 ABCG2
dbSNP Gene:9429 ABCG2
ENSEMBL:ENSG00000118777 ABCG2
HGNC:74 ABCG2
KEGG:hsa:9429 ABCG2
Monarch:9429 ABCG2
NCBI Entrez Gene:9429 ABCG2
OMIM:603756 ABCG2
UCSC:Q9UNQ0 ABCG2
Reference Transcript
RefSeq:NM_001348985.1 ABCG2
RefSeq:NM_004827.3 ABCG2
RefSeq:XM_011532420.4 ABCG2
RefSeq:NM_001257386.2 ABCG2
RefSeq:NM_001348989.2 ABCG2
RefSeq:NM_001348986.1 ABCG2
RefSeq:XM_054351284.1 ABCG2
RefSeq:NM_001348988.1 ABCG2
RefSeq:XM_005263355.3 ABCG2
Other Identifiers
11724537_a_at
11724538_a_at
16977868
209735_PM_at
209735_at
2777284
2777285
2777286
2777287
2777288
2777289
2777290
2777291
2777292
2777293
2777295
2777296
2777297
2777298
2777299
2777300
2777301
2777303
2777305
2777306
2777307
2777308
2777309
2777310
2777312
2777313
2777314
2777315
2777316
33733_at
8101675
9429
A_23_P18713
A_33_P3361067
GE575063
GE81445
GO:0000166
GO:0003013
GO:0003014
GO:0005215
GO:0005515
GO:0005524
GO:0005654
GO:0005739
GO:0005886
GO:0006629
GO:0006869
GO:0008514
GO:0008559
GO:0015143
GO:0015225
GO:0015562
GO:0015711
GO:0015747
GO:0015878
GO:0016020
GO:0016324
GO:0016787
GO:0016887
GO:0030148
GO:0031526
GO:0031966
GO:0032217
GO:0032218
GO:0042626
GO:0042802
GO:0042803
GO:0042910
GO:0045121
GO:0046415
GO:0046624
GO:0046983
GO:0055085
GO:0070633
GO:0097744
GO:0098591
GO:0098754
GO:0140115
GO:0140359
GO:0150104
GO:1990748
GO:1990962
HMNXSV003049042
ILMN_1789641
PH_hs_0011514
TC04001370.hg
TC04002625.hg
g12414050_3p_at
Participates
as a component of
ABCG2 tetramer [apical plasma membrane] (Homo sapiens)
Other forms of this molecule
HC-ABCG2 [plasma membrane]
Inferred To
Abcg2 [apical plasma membrane]
(Canis familiaris)
ABCG2 [apical plasma membrane]
(Bos taurus)
Homologues of HC-ABCG2 [apical plasma membrane]
(Caenorhabditis elegans)
Homologues of HC-ABCG2 [apical plasma membrane]
(Dictyostelium discoideum)
Homologues of HC-ABCG2 [apical plasma membrane]
(Drosophila melanogaster)
Homologues of HC-ABCG2 [apical plasma membrane]
(Sus scrofa)
abcg2 [apical plasma membrane]
(Xenopus tropicalis)
abcx-1 [apical plasma membrane]
(Caenorhabditis elegans)
wht-5 [apical plasma membrane]
(Caenorhabditis elegans)
ABCG2A [apical plasma membrane]
(Sus scrofa)
HC-ABCG2 [apical plasma membrane]
(Dictyostelium discoideum)
HC-ABCG2 [apical plasma membrane]
(Drosophila melanogaster)
HC-ABCG2 [apical plasma membrane]
(Mus musculus)
HC-ABCG2 [apical plasma membrane]
(Plasmodium falciparum)
HC-ABCG2 [apical plasma membrane]
(Rattus norvegicus)
HC-ABCG2 [apical plasma membrane]
(Saccharomyces cerevisiae)
HC-ABCG2 [apical plasma membrane]
(Sus scrofa)
CG18633 [apical plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
L-cystine (cross-link) at 603
Coordinate
603
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
NP_001335914.1
,
NP_001244315.1
,
XP_011530722.1
,
NP_001335917.1
,
NP_001335915.1
,
XP_054207259.1
,
NP_001335918.1
,
XP_005263412.1
,
NP_004818.2
ZINC - World Drugs
ABCG2_HUMAN
Guide to Pharmacology - Targets
792
OpenTargets
ENSG00000118777
ENSEMBL
ENSP00000237612
,
ENSP00000498246
,
ENST00000515655
,
ENSG00000118777
,
ENST00000237612
,
ENSP00000426917
,
ENST00000650821
ZINC - FDA approved
ABCG2_HUMAN
ZINC - Substances
ABCG2_HUMAN
ZINC - Biogenic
ABCG2_HUMAN
ZINC target
Q9UNQ0
PRO
Q9UNQ0
GlyGen
Q9UNQ0
PDB
8P8A
,
7NEQ
,
5NJ3
,
8P8J
,
7OJ8
,
6HBU
,
7NEZ
,
6HIJ
,
7OJH
,
8U2C
,
5NJG
,
6FEQ
,
7OJI
,
7NFD
,
6HCO
,
8QCM
,
6ETI
,
6HZM
,
8Q7B
,
6VXI
,
6VXH
,
8BI0
,
8PY4
,
6FFC
,
8PXO
,
6VXF
,
6VXJ
,
8P7W
,
8BHT
ZINC - Investigational
ABCG2_HUMAN
ZINC - Metabolites
ABCG2_HUMAN
HPA
ENSG00000118777-ABCG2
GeneCards
ABCG2
Pharos - Targets
Q9UNQ0
ZINC - Predictions - Purchasable
ABCG2_HUMAN
HMDB Protein
HMDBP02257
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UNQ0 ABCG2
2
HC-ABCG2 [plasma membrane]
(R-HSA-917929)
HC-ABCG2 [apical plasma membrane]
(R-HSA-9794401)
0.791
5
UniProt:P11309-2 PIM1
0.639
5
UniProt:P22413 ENPP1
1
ENPP1 [plasma membrane]
(R-HSA-196973)
0.602
4
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