Expression of MESP2 in presomitic mesoderm

Stable Identifier
R-HSA-9793933
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of MESP2 in presomitic mesoderm
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MESP2 is expressed in the presomitic mesoderm (Xi et al. 2017 and inferred from mouse homologs). TBX6 binds the MESP2 enhancer and is required for expression of MESP2 in paraxial mesoderm (inferred from mouse homologs). NOTCH signaling strongly enhances the activation of MESP2 by TBX6 (inferred from mouse homologs). FOXC1 and FOXC2 are also required for expression of MESP2 in paraxial mesoderm (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
28178531 In Vivo Human Somitogenesis Guides Somite Development from hPSCs

Liebscher, S, Xi, H, Schenke-Layland, K, Gonzalez, K, Fujiwara, W, Pyle, AD, Van Handel, B, Jan, M

Cell Rep 2017
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TBX6:MESP2 gene [nucleoplasm] (Homo sapiens)
Active Unit
TBX6 [nucleoplasm]
Inferred From
Expression of Mesp2 in presomitic mesoderm (Mus musculus)
Authored
May, B  (2022-06-19)
Reviewed
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Created
May, B  (2022-06-24)
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