Cipro HCl dissolves

Stable Identifier
R-HSA-9793564
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Cipro HCl dissolves
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At low pH less than 5.0, as is typical for the upper GI tract, ciprofloxacin HCl dissolves, with the Cipro(1+) ion the preferred species at that pH. The upper GI tract also appears to be the main absorption site (Harder et al, 1990; reviewed by Olivera et al, 2010).
Literature References
PubMed ID Title Journal Year
20602455 Biowaiver monographs for immediate release solid oral dosage forms: ciprofloxacin hydrochloride

Midha, KK, Stavchansky, S, Manzo, RH, Junginger, HE, Dressman, JB, Barends, DM, Olivera, ME, Shah, VP

J Pharm Sci 2011
2390430 Ciprofloxacin absorption in different regions of the human gastrointestinal tract. Investigations with the hf-capsule

Fuhr, U, Beermann, D, Staib, AH, Harder, S

Br J Clin Pharmacol 1990
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Authored
Stephan, R  (2022-06-21)
Reviewed
Thorn, CF  (2022-11-09)
Created
Stephan, R  (2022-06-21)
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