NOTCH1 coactivator complex binds the TBX6 gene

Stable Identifier
R-HSA-9793400
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH1 coactivator complex binds the TBX6 gene
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NOTCH signaling activates TBX6 expression in paraxial mesoderm via RBPJ, which binds a site in the promoter of the TBX6 gene (inferred from mouse and Drosophila homologs). RBPJ is inferred to bind other members of the NOTCH1 coactivator complex in order to activate transcription of TBX6.
Participants
Input
Output
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as an event of
Inferred From
SU(H) binds the Tbx6 gene (Drosophila melanogaster)
Authored
May, B  (2022-06-12)
Reviewed
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Created
May, B  (2022-06-12)
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