Reactome | SUMOylation of nuclear envelope proteins

SUMOylation of nuclear envelope proteins

Stable Identifier

R-HSA-9793242

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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SUMOylation of nuclear envelope proteins

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SUMOylation of RANGAP1 (Mahajan et al. 1997, Lee et al. 1998, Knipscheer et al. 2008) and LMNA (Zhang and Sarge 2008) affect their localization at the nuclear envelope. SUMOylation of NUP153 has unknown consequences (Chow et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
18691969	Ubc9 sumoylation regulates SUMO target discrimination Sixma, TK, Fish, A, Olsen, JV, Klug, H, Pichler, A, Flotho, A, Johnson, ES, van Dijk, WJ, Mann, M, Knipscheer, P	Mol. Cell	2008
9019411	A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2 Guan, T, Gerace, L, Melchior, F, Mahajan, R, Delphin, C	Cell	1997
18606848	Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies Sarge, KD, Zhang, YQ	J Cell Biol	2008
9497385	Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue Tian, Q, Anderson, P, Matunis, MJ, Melchior, F, Mahajan, R, Lee, GW	J. Biol. Chem.	1998