CD55 (DAF) promotes C3bBb/C4bC2a dissociation

Stable Identifier
R-HSA-977619
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Decay accelerating factor (DAF, CD55) is a widely distributed membrane protein. It accelerates the dissociation of C3bBb and C4C2a, thereby inhibiting the amplification of complement. DAF can bind C3b and Bb but must bind both for efficient decay acceleration. The regulatory function of DAF is believed to be inhibition of activated C3 convertase enzymes rather than binding of inactive proenzymes (Harris et al. 2007).

Literature References
PubMed ID Title Journal Year
8786315 Localization of classical and alternative pathway regulatory activity within the decay-accelerating factor

Brodbeck, WG, Liu, D, Sperry, J, Mold, C, Medof, ME

J Immunol 1996
6238120 Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes

Medof, ME, Kinoshita, T, Nussenzweig, V

J Exp Med 1984
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