Factor I inactivates MCP/CR1-bound C4b/C3b

Stable Identifier
R-HSA-977615
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Factor I (CFI) cleaves the truncated alpha (a') chain of C4b between Arg-1336 and Asn-1337 and then again between Arg-956 and Thr-957, producing a 16 kDa fragment known as alpha4, derived from the C terminus of the a' chain, followed by a 27 kDa alpha3 fragment. The remaining alpha 2 (C4d) fragment stays covalently bound to the cell membrane while the complex of disulfide-linked alpha3, alpha4, beta chain and gamma chain are released (C4c) into the fluid phase (Fujita et al. 1978).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of CFI:CD46, CR1:C4b, C3b complexes [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created