Reactome | KCNH2 [plasma membrane]

KCNH2 [plasma membrane]

Stable Identifier

R-HSA-977529

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium voltage-gated channel subfamily H member 2, KCNH2_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Voltage gated Potassium channels (Homo sapiens)
    - Activation of voltage gated Potassium channels (Homo sapiens)
      - Octamer of Voltage gated K+ channels [plasma membrane] (Homo sapiens)
        
        Voltage gated potassium channel subunits Kv1-12 [plasma membrane] (Homo sapiens)
        
        Kv11 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)
        
        KCNH2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12809 KCNH2

Gene Names

KCNH2, ERG, ERG1, HERG

Chain

chain:1-1159

Reference Genes

BioGPS Gene:3757 KCNH2

COSMIC (genes):ERG ERG

COSMIC (genes):KCNH2 KCNH2

CTD Gene:3757 KCNH2

dbSNP Gene:3757 KCNH2

ENSEMBL:ENSG00000055118 KCNH2

HGNC:6251 KCNH2

KEGG:hsa:3757 KCNH2

Monarch:3757 KCNH2

NCBI Gene:3757 KCNH2

OMIM:152427 KCNH2

UCSC:Q12809 KCNH2

Reference Transcript

Other Identifiers

11727280_a_at

11733662_a_at

11752635_x_at

17064299

205262_PM_at

205262_at

210036_PM_s_at

210036_s_at

3079208

3079209

3079210

3079211

3079212

3079213

3079214

3079215

3079216

3079217

3079218

3079219

3079220

3079221

3079222

3079223

3079224

3079225

3079226

3079227

3079228

3079229

3079230

3079231

3079232

3079234

3079235

3079236

3079237

3079238

3079239

3079240

3079241

3079247

3079248

3079250

3079251

3757

38225_at

38858_at

8143825

A_23_P168403

A_23_P377882

GE61879

GO:0000976

GO:0003012

GO:0003064

GO:0003677

GO:0005215

GO:0005216

GO:0005242

GO:0005249

GO:0005251

GO:0005267

GO:0005515

GO:0005886

GO:0006355

GO:0006811

GO:0006813

GO:0008076

GO:0009986

GO:0016020

GO:0031625

GO:0034702

GO:0042391

GO:0042802

GO:0042803

GO:0045893

GO:0048471

GO:0055075

GO:0055085

GO:0060048

GO:0060306

GO:0060307

GO:0071466

GO:0071805

GO:0086005

GO:0086009

GO:0086010

GO:0086011

GO:0086013

GO:0086091

GO:0097110

GO:0097623

GO:0098655

GO:0098915

GO:1901379

GO:1901380

GO:1901381

GO:1902282

GO:1902937

GO:1903765

GO:1990573

HMNXSV003011496

HMNXSV003053177

ILMN_1700798

ILMN_1722831

ILMN_1739987

ILMN_2338809

PH_hs_0011011

TC07002024.hg

U04270_at

g11933151_3p_a_at

g4557728_3p_at

Participates

as a member of

Kv11 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)

as a component of

KCNH2:KCNE [plasma membrane] (Homo sapiens)

Inferred To

kcnh2 [plasma membrane] (Xenopus tropicalis)

Kcnh2 [plasma membrane] (Mus musculus)

Kcnh2 [plasma membrane] (Rattus norvegicus)

KCNH2 [plasma membrane] (Bos taurus)

KCNH2 [plasma membrane] (Canis familiaris)

KCNH2 [plasma membrane] (Gallus gallus)

KCNH2 [plasma membrane] (Sus scrofa)

sei [plasma membrane] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

572

OpenTargets

ENSG00000055118

ENSEMBL

ENSP00000262186, ENST00000262186, ENSG00000055118, ENSP00000328531, ENST00000330883

ZINC - FDA approved

KCNH2_HUMAN

ZINC - Substances

KCNH2_HUMAN

ZINC - Biogenic

KCNH2_HUMAN

ZINC target

Q12809

PRO

Q12809

GlyGen

Q12809

PDB

2L0W, 5VA1, 1UJL, 8IO5, 9CHR, 2LE7, 8IO4, 2N7G, 4HP9, 1BYW, 9CHS, 2L4R, 8ZYN, 8ZYQ, 9CHQ, 8ZYO, 2L1M, 9CHP, 4HQA, 8ZYP, 5VA3, 5VA2, 6SYG, 8IOB

ZINC - Investigational

KCNH2_HUMAN

ZINC - Metabolites

KCNH2_HUMAN

HPA

ENSG00000055118-KCNH2

GeneCards

KCNH2

Pharos - Targets

Q12809

Orphanet

KCNH2

ZINC - Predictions - Purchasable

KCNH2_HUMAN

HMDB Protein

HMDBP02212