Reactome | KCNA1 [plasma membrane]

KCNA1 [plasma membrane]

Stable Identifier

R-HSA-977482

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium voltage-gated channel subfamily A member 1, KCNA1_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Voltage gated Potassium channels (Homo sapiens)
    - Activation of voltage gated Potassium channels (Homo sapiens)
      - Octamer of Voltage gated K+ channels [plasma membrane] (Homo sapiens)
        
        Voltage gated potassium channel subunits Kv1-12 [plasma membrane] (Homo sapiens)
        
        Kv1 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)
        
        KCNA1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q09470 KCNA1

Gene Names

KCNA1

Chain

chain:1-495

Reference Genes

BioGPS Gene:3736 KCNA1

COSMIC (genes):KCNA1 KCNA1

CTD Gene:3736 KCNA1

dbSNP Gene:3736 KCNA1

ENSEMBL:ENSG00000111262 KCNA1

HGNC:6218 KCNA1

Monarch:3736 KCNA1

NCBI Gene:3736 KCNA1

OMIM:176260 KCNA1

UCSC:Q09470 KCNA1

Reference Transcript

RefSeq:NM_000217.2 KCNA1

Other Identifiers

11728995_at

11728996_at

16747121

208479_PM_at

208479_at

230849_PM_at

230849_at

33939_at

3401995

3401996

3401997

3401999

3402000

3402001

3402002

3402003

3402004

3402005

3402006

3402007

3402008

3736

44759_at

71206_at

7953274

A_14_P102348

A_23_P48229

GE57548

GE85472

GE905355

GO:0001508

GO:0001964

GO:0005215

GO:0005216

GO:0005249

GO:0005251

GO:0005267

GO:0005515

GO:0005783

GO:0005829

GO:0005886

GO:0006811

GO:0006813

GO:0006937

GO:0007405

GO:0007420

GO:0008076

GO:0008104

GO:0009986

GO:0010644

GO:0010960

GO:0016020

GO:0016324

GO:0019228

GO:0021554

GO:0021766

GO:0021987

GO:0022038

GO:0023041

GO:0030054

GO:0030424

GO:0030425

GO:0031410

GO:0033270

GO:0034702

GO:0034705

GO:0042391

GO:0042734

GO:0042995

GO:0043025

GO:0043194

GO:0043204

GO:0043226

GO:0043679

GO:0044224

GO:0044305

GO:0045202

GO:0045211

GO:0048856

GO:0050877

GO:0050905

GO:0050966

GO:0050976

GO:0051260

GO:0055085

GO:0060078

GO:0061564

GO:0065003

GO:0070161

GO:0071286

GO:0071805

GO:0086011

GO:0097718

GO:0098793

GO:0098978

GO:0099505

GO:0099508

GO:1905030

HMNXSV003024953

Hs.22999.0.A1_3p_at

ILMN_1670954

ILMN_1872462

ILMN_1891607

PH_hs_0003874

TC12000068.hg

TC12002188.hg

g4557684_3p_at

Participates

as a member of

Kv1 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)

Inferred To

Sh [plasma membrane] (Drosophila melanogaster)

kcna1 [plasma membrane] (Xenopus tropicalis)

KCNA1 [plasma membrane] (Bos taurus)

KCNA1 [plasma membrane] (Canis familiaris)

KCNA1 [plasma membrane] (Sus scrofa)

Kcna1 [plasma membrane] (Mus musculus)

Kcna1 [plasma membrane] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

538

ENSEMBL

ENSP00000371985, ENST00000382545

OpenTargets

ENSG00000111262

HPA

ENSG00000111262-KCNA1

ZINC - Substances

KCNA1_HUMAN

ZINC target

Q09470

PRO

Q09470

Pharos - Targets

Q09470

GlyGen

Q09470

Orphanet

KCNA1

ZINC - Predictions - Purchasable

KCNA1_HUMAN

HMDB Protein

HMDBP10840

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78352 DLG4	3	DLG4 [plasma membrane] (R-HSA-202135) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [cytosol] (R-HSA-6794267)	0.558	2
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.556	7