CDH19 gene expression is stimulated by ZC3H12A

Stable Identifier
R-HSA-9774168
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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CDH19 gene expression is stimulated by ZC3H12A
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Treatment of human umbilical vein endothelial cells (HUVECs) with MCP-1 (monocyte chemotactic protein 1, also known as CCL2 or C-C motif chemokine 2) or transfection of HUVECs with a ZC3H12A (also known as MCPIP, for MCP-1 induced protein) expression vector leads to upregulation of CDH19 and CDH12. In human embryonic kidney cell line HEK293, exogenously expressed human ZC3H12A was shown by chromatin immunoprecipitation (ChIP) to bind to the promoters of CDH19 and CDH12 genes, so ZC3H12A-mediated upregulation of CDH19 and CDH12 is thought to be direct (Niu et al. 2008). The upregulation of CDH19 and CDH12 in human bone marrow mononuclear cells (BMNCs) in response to MCP-1 was also shown to be dependent on ZC3H12A (Niu et al. 2013).
Literature References
PubMed ID Title Journal Year
24008336 MCP-1-induced protein promotes endothelial-like and angiogenic properties in human bone marrow monocytic cells

Niu, J, Kolattukudy, PE, Wang, K, Saad, Y, Zhelyabovska, O

J Pharmacol Exp Ther 2013
18364357 Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP)

Niu, J, Kolattukudy, PE, Fatma, S, Zhelyabovska, O, Azfer, A

J Biol Chem 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ZC3H12A:CDH19 gene [nucleoplasm] (Homo sapiens)
Active Unit
ZC3H12A [nucleoplasm]
Authored
Orlic-Milacic, M  (2022-05-25)
Reviewed
Brasch, J  (2023-04-18)
Created
Orlic-Milacic, M  (2022-05-19)
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