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CD46 [plasma membrane]
Stable Identifier
R-HSA-977362
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Membrane cofactor protein, MCP_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P78504%20JAG1
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
CD46 binds C3b (Homo sapiens)
CD46 [plasma membrane] (Homo sapiens)
CD46 binds C4b (Homo sapiens)
CD46 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15529 CD46
Gene Names
CD46, MCP, MIC10
Chain
signal peptide:1-34, chain:35-392
Reference Genes
BioGPS Gene:4179 CD46
COSMIC (genes):CD46 CD46
CTD Gene:4179 CD46
dbSNP Gene:4179 CD46
ENSEMBL:ENSG00000117335 CD46
ENSEMBL_homo_sapiens_GENE:ENSG00000117335.21 CD46
HGNC:6953 CD46
KEGG Gene (Homo sapiens):4179 CD46
Monarch:4179 CD46
NCBI Gene:4179 CD46
OMIM:120920 CD46
UCSC:P15529 CD46
Reference Transcript
RefSeq:NM_172359.2 CD46
RefSeq:NM_172353.2 CD46
RefSeq:NM_172352.2 CD46
RefSeq:NM_172351.2 CD46
RefSeq:XM_017001310.1 CD46
RefSeq:NM_172350.2 CD46
RefSeq:NM_153826.3 CD46
RefSeq:XM_017001309.1 CD46
RefSeq:NM_002389.4 CD46
RefSeq:XM_017001308.1 CD46
RefSeq:XM_011509563.1 CD46
RefSeq:XM_011509564.1 CD46
RefSeq:NM_172361.2 CD46
Other Identifiers
11718970_a_at
11718971_x_at
11720595_a_at
11735060_a_at
11735681_x_at
11742219_a_at
11742220_x_at
11743903_a_at
11751532_x_at
11751549_a_at
11751550_x_at
11755715_x_at
16676893
207549_PM_x_at
207549_x_at
208783_PM_s_at
208783_s_at
211574_PM_s_at
211574_s_at
2377431
2377433
2377455
2377456
2377457
2377458
2377459
2377462
2377463
2377464
2377466
2377471
2377472
2377474
2377476
2377481
2377485
2377488
2377490
2377491
2377497
2377498
2377503
2377504
2377505
2377506
2377507
2377508
38441_s_at
4179
7909400
A_23_P201758
A_23_P35230
A_24_P282597
GE59843
GO:0001618
GO:0002079
GO:0002250
GO:0002376
GO:0002456
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005925
GO:0006958
GO:0007155
GO:0007338
GO:0008593
GO:0009986
GO:0010628
GO:0010629
GO:0016020
GO:0022414
GO:0023052
GO:0030154
GO:0031410
GO:0032733
GO:0035581
GO:0038023
GO:0042102
GO:0043226
GO:0043382
GO:0045087
GO:0045296
GO:0045591
GO:0045959
GO:0046718
GO:0048856
GO:0060089
GO:0070062
GO:0071636
GO:0098542
HMNXSV003057394
Hs.83532.1.A2_3p_a_at
ILMN_2307740
ILMN_2307744
PH_hs_0004767
TC01001741.hg
X59405_at
g11321566_3p_a_at
Participates
as an input of
CD46 binds C4b (Homo sapiens)
CD46 binds C3b (Homo sapiens)
as a member of
CD46, CR1 [plasma membrane] (Homo sapiens)
as a component of
CD46:Cell surface:C4b [plasma membrane] (Homo sapiens)
CD46:Cell surface:C3b [plasma membrane] (Homo sapiens)
Inferred To
Homologues of CD46 [plasma membrane]
(Gallus gallus)
Cd46 [plasma membrane]
(Mus musculus)
Cd46 [plasma membrane]
(Rattus norvegicus)
LOC102156626 [plasma membrane]
(Canis familiaris)
CD46 [plasma membrane]
(Bos taurus)
CD46 [plasma membrane]
(Gallus gallus)
CD46 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_011507866.1
,
XP_016856799.1
,
NP_758871.1
,
NP_758863.1
,
XP_016856798.1
,
NP_758862.1
,
NP_758861.1
,
NP_758860.1
,
XP_016856797.1
,
NP_722548.1
,
NP_002380.3
,
NP_758869.1
,
XP_011507865.1
OpenTargets
ENSG00000117335
HPA
ENSG00000117335-CD46
GeneCards
P15529
Ensembl
ENSP00000356008
,
ENST00000322918
,
ENSP00000350346
,
ENST00000322875
,
ENST00000367047
,
ENST00000367042
,
ENSP00000356014
,
ENST00000354848
,
ENST00000358170
,
ENSP00000350893
,
ENST00000360212
,
ENSP00000346912
,
ENST00000367041
,
ENSP00000356009
,
ENST00000480003
,
ENSP00000353342
,
ENST00000357714
,
ENSP00000313875
,
ENSG00000117335
,
ENSP00000314664
,
ENSP00000418471
PRO
P15529
Pharos - Targets
P15529
Orphanet
15416
PDB
5FO8
,
3O8E
,
2O39
,
3L89
,
3INB
,
1CKL
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-12735745 C3B
0.761
4
UniProt:P78504 JAG1
2
Ub-JAG1 [plasma membrane]
(R-HSA-9013079)
JAG1 [plasma membrane]
(R-HSA-157098)
0.632
5
UniProt:P01024 C3
20
C3d fragment [extracellular region]
(R-HSA-198999)
C3 alpha chain [azurophil granule lumen]
(R-HSA-6799161)
C3 beta chain [azurophil granule lumen]
(R-HSA-6799159)
C3 alpha chain [secretory granule lumen]
(R-HSA-6800982)
C3 beta chain [secretory granule lumen]
(R-HSA-6801014)
p-C3 [endoplasmic reticulum lumen]
(R-HSA-8957056)
C3 [endoplasmic reticulum lumen]
(R-HSA-8956774)
C3c alpha' chain fragment 1 precursor [extracellular region]
(R-HSA-976816)
C3c alpha' chain fragment 2 [extracellular region]
(R-HSA-976818)
C3c alpha' chain fragment 1 [extracellular region]
(R-HSA-3266502)
C3a-desArg [extracellular region]
(R-HSA-8852808)
C3dg [plasma membrane]
(R-HSA-3266505)
C3d [plasma membrane]
(R-HSA-8853248)
C3f [extracellular region]
(R-HSA-976779)
C3 beta chain [plasma membrane]
(R-HSA-977593)
C3c alpha' chain fragment 1 precursor [plasma membrane]
(R-HSA-977595)
C3c alpha' chain fragment 2 [plasma membrane]
(R-HSA-977594)
C3 alpha chain [extracellular region]
(R-HSA-166820)
C3b alpha' [extracellular region]
(R-HSA-166830)
C3 beta chain [extracellular region]
(R-HSA-166821)
0.623
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
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